Modelarea, Proiectarea si Analiza Sistemelor Sintetice Capabile de Auto-asamblare MoDASyS




The National Institute for Research and Development for Biological Sciences in Bucharest (INCDSB) started the implementation of the project "Modeling, Designing and Analysis of Synthetic Self-assembled Systems - MoDASyS", co-financed by the European Regional Development Fund through Competitiveness Operational Program 2014-2020. The total value of the project is 1,849,546.2Euro, 1,561,756.8Euro representing the co-financing of the European Regional Development Fund and 287,789.4Euro representing the co-financing of the Government of Romania, based on the contract no. 24 from 01.09.2016 signed with the National Authority for Scientific Research and Innovation as an Intermediate Body on behalf of the Ministry of European Funds as Managing Authority for the Competitiveness Operational Program. The project is being implemented in Bucharest over a 48 month period. The overall scientific objective of the project is to introduce and develop DNA-based nanotechnology research in Romania and to increase the Romanian researchers' capacities and competences in this area. This objective will be achieved by carrying out research activities in the field of nanotechnology, through the participation of a researcher from abroad, with concrete results in the field, and which will lead at the scientific level the team of researchers of the INCDSB institute. The investment is designed to help transform the INCDSB into a European Center for Computational Nanotechnology for DNA, proposing also the support of 6 new researchers at the INCDSB, the publication of 20 scientific papers, and the submission of 3 project proposals for Horizon 2020 competition. The specific scientific activities developed in the project will be focused on two priority axes, namely: 1. Automating the design process of DNA structures in order to achieve nano-processing capabilities similar to the 3D printing process. 2. Develop a systematic discipline through which the structural and dynamic tools of DNA Nanotechnology are brought together to create coordinated nanosystems (using DNA material) to perform well-defined, well-defined actions. Project co-financed from the European Regional Development Fund through the Competitiveness Operational Program 2014-2020.

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WP1 A kinetic modeling framework for DNA self-assembly systems

One of the main objectives of the project is to develop a generic kinetic modeling framework for DNA assembly systems where any dynamic mechanism based on nucleic acid interactions can be integrated and numerically simulated. Such a generic framework will allow the kinetic modeling of a combination of interconnected mechanisms that can evolve simuntaneously and which can interact within an integrated system. An example of such a system are the composite systems where cascade disruptive modules of DNA sequencesc could promote or inhibit the interaction of structural modules such as DNA plaques or DNA-Origami structures.

WP 2 Algorithmic assembling of three-dimensional nano-structures

A central research direction of the project is to develop the theoretical basis of the new algorithm method of constructing three-dimensional nano-structures (3D), using the DNA-BEAM triangular structure based technique. This technique proposes to assemble 3D polugonal nano-structures by reconstructing their outer skeleton using a triangular beam system implemented from DNA material. The structure obtained will have structural integrity to the triangularization of the component beams, and the construction material, i.e. the DNA material, will be used in an unequivocally effective manner.

WP3 Innovative Assembly Schemes: Design/ Simulation/ Implementation

Applying the generic kinetic modeling framework of DNA self-assembling systems to analyze from a kinetic perspective a number of innovative and efficient models of DNA self-assembling systems. We want to focus in first place on autonomus DNA systems based on succesive assemblies, of DNA system whose assembly is governed by molecular signals, as well as systems for assembling of other organic or anorganic materials using DNA as a targeting factor for assembling.

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Project Leaders





Eugen Czeizler
eugen.czeizler@incdsb.ro

Andrei Paun
andrei.paun@incdsb.ro

Mihaela Paun
mihaela.paun@incdsb.ro

Ion Petre
ion.petre@incdsb.ro



Implementation Team





Alexandru Amarioarei
alexandru.amarioarei@incdsb.ro

Iris Tusa
iris.tusa@incdsb.ro

Corina Itcus
corina.itcus@incdsb.ro

Romica Trandafir
romica.trandafir@incdsb.ro

Victor Mitrana
victor.mitrana@incdsb.ro

Ana Maria Gheorghe
AnaMaria.Gheorghe@incdsb.ro

Gefry Barad
gefry.barad@incdsb.ro

Daniela Cheptea
daniela.cheptea@incdsb.ro

Daniela Cheptea
daniela.cheptea@incdsb.ro

Daniela Cheptea
daniela.cheptea@incdsb.ro



Project Manager





Manuela Sidoroff
manuela.sidoroff@incdsb.ro



Management team





Cosmina Panzaru
cosmina.panzaru@incdsb.ro

Gabriela Zaheu
gabriela.zaheu@incdsb.ro

Laura Stancu
laura.stancu@incdsb.ro

Mircea Juganaru
mircea.juganaru@incdsb.ro

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Contact


The National Institute of Research and Development for Biological Sciences 296 Independenței Bd. District 6, 060031 Bucharest
Phone: 021-220.77.80 Fax: 021-220.76 95
www.incdsb.ro office@incdsb.ro