Diseminarea rezultatelor

Articole stiintifice

1. Gaspar-Pintiliescu A, Seciu-Grama AM, Prelipcean AM, Alecu A, Gatea F, Zarnescu O, Negreanu-Pirjol T, Craciunescu O (2024) Skin anti-aging potential of sulfated polysaccharides from Cladophora vagabunda green seaweed, Heliyon (in evaluare)

2. Gaspar-Pintiliescu A, Stefan LM, Mihai E, Sanda C, Manoiu VS, Berger D, Craciunescu O (2024) Antioxidant and antiproliferative effect of a glycosaminoglycan extract from Rapana venosa marine snail. Plos One, 19(2), e0297803

3. Mihai E, Gaspar-Pintiliescu A, Ciucan T, Prelipcean AM, Tomescu J, Neagu M, Craciunescu O (2023) Comparative study on the composition, antioxidant and antimicrobial activity of fennel hydrolates, Scientific Bulletin Series F Biotechnologies, vol XXVII, 1, 67-74.

Participari la conferinte internationale

1. Gaspar-Pintiliescu A, Iosageanu A, Coroiu V, Zarnescu O, Craciunescu O, Novel mixtures of bioactive compounds from Black Sea sources of fish skin and green seaweed with wound healing properties, 10^th International Conference on Sustainable Solid Waste Management, Chania, Greece, 21-24 June, 2023, poster number 109.

2. Gaspar-Pintiliescu A, Seciu-Grama AM, Gatea F, Coroiu V, Craciunescu O, Zarnescu O, Characterization of Cladophora vagabunda seaweed polysaccharidic extract and its anti-collagenase, anti-elastase and anti-metalloproteinase activity, 5^th International Conference on Natural Products Utilization, from Plants to Phamacy Shelf, Sts. Constantine and Helena Resort, Bulgaria, 30 May-2 June 2023, abstract publicat in Book of Abstracts, pag. 158.

3. Gaspar-Pintiliescu A, Utoiu E, Mihai E, Prelipcean AM, Popescu AF, Craciunescu O, Phenolic content and in vitro antioxidant and antimicrobial potential of wormwood hydrosols, (online poster, poster number 73), 15^th World Congress on Polyphenols Applications, 28-30 sept 2022, Valencia, Spain, abstract publicat in Polyphenols Applications Abstracts Book 2022, pag 100.
4. Gaspar-Pintiliescu A, Seciu-Grama AM, Mihai E, Zarnescu O, Craciunescu O, Chemical content and anti-inflammatory potential of sulfated polysaccharides from Cladophora vagabunda seaweed, (poster presentation, poster number 56), Natural Products in Drug Discovery and Development - Advances and Perspectives (Phytochemical Society of Europe Meeting 2022), 19-22 sept 2022, Iasi, Romania, abstract publicat online in Abstracts Book, pag 170.

Cerere brevet

Gaspar-Pintiliescu A, Craciunescu O, Seciu-Grama AM, Iosageanu A, Prelipcean AM, Hidrogel multifunctional pe baza de componente de origine marina si vegetala pentru tratamentul ranilor cronice si procedeu de obtinere, OSIM, A/00755 din 28.11.2023

Pagina web a proiectului

Proiectul a condus la formularea si brevetarea unei compozitii naturale sinergice, sub forma de hidrogel, pe baza de compusi marini de natura proteica si polizaharidica, suplimentata cu o nanoemulsie din componente de origine vegetala si destinata tratamentului ranilor cronice. Asocierea gelatinei obtinuta din deseuri de piele de peste (Dicentrarchus labrax) cu polizaharidele extrase din alge verzi (Cladophora vagabunda) si cu nanoemulsia de pelin (Artemisia absinthium) a condus la obtinerea unui nou hidrogel multifunctional cu efect direct asupra proceselor implicate in cronicizarea ranilor. Modelele experimentale propuse au demonstrat eficienta hidrogelului impotriva raspunsului inflamator excesiv, supraproductiei de metaloproteinaze matriceale si infectiilor persistente, procese responsabile de intarzierea procesului de vindecare normal la nivelul pielii.